Endocrine Abstracts

Introduction: Even if breast cancer is rare cause of pituitary metastases, the diagnosis of a pituitary adenoma, shortly after surgery for breast cancer, raises suspicion of a possible secondary determinations.Material and method: This is a case report revealing the medical history and endocrine profile of a female with breast cancer and pituitary macroadenoma.Case data: A 64-year old non-smoking female (with menopause at age of 52...

Introduction: Cushing’s disease (CD) is caused by high adrenocorticotropic hormone (ACTH), usually by a pituitary microadenoma.Material and method: This is a case report investigated in several Romanian centers by performing: morning plasma cortisol, circadian rhythm of plasma cortisol, plasma ACTH, dexamethasone (DXM) suppression tests.Case data: A 57-year female, known with hypertension and osteopenia, was ...

Introduction: Cushing’s syndrome (CS) is correlated with prolonged exposure to high levels of glucocorticoid hormones. Although the most common cause is exogenous adrenal tumors incidentally discovered (incidentaloma) may underline CS.Material and method: This is a case presentation of an adult patient. Specific tests for CS have been used: morning plasma cortisol and circadian rhythm, plasma ACTH, testosterone, dexamethasone (DXM) suppression test....

Introduction: The hypoparathyroidism (HypoPT) represents a rare condition characterized by low calcium (Ca) and parathyroid hormone (PTH) levels, frequently due to thyroid surgery by direct trauma of the parathyroid glands, devascularization, or their accidental removal. Postoperative hypoparathyroidism-related hypocalcemia may be permanent or transient.Case report: We report the case of a 64-year-old man presenting with severe symptoms of hypocalcemia (...

Introduction: Paraneoplastic Cushing syndrome is a rare form of endogenous ACTH (adrenocorticotropic hormone) dependent hypercortisolism. In some cases no overt ACTH secretion tumor can be found, which is why steroidogenesis inhibitors, and bilateral adrenalectomy remain the main therapeutic options.Material and method: This is a case report investigated in several centers by performing biochemical, hormonal and imagery tests.Case ...

Introduction: Bulimia is an eating disorder characterized by constant preoccupation with food, irresistible cravings for food and binge eating episodes. The data regarding the incidence of bulimia in people with diabetes are contradictory. The glycemic variations subsequent to binging and vomiting leads to complications like retinopathy, kidney or liver failure, hypoglycemic comas and electrolyte imbalances.Case presentation: A 57-year-old female, diagno...

Introduction: Pain in the groin area is frequently encountered in football players, the cause being a sport hernia, muscle tears, avulsions, sacroiliac joint pathology, etc. Local corticosteroid injections (LCIs) are often used as one of the first-line treatments in the conservative management because of their ease of delivery, low cost and efficacy.Case presentation: A 32-year-old amateur futsal player (goalkeeper) diagnosed with type 1 diabetes at the ...

Adrenocorticotropic hormone (ACTH) adenomas causing Cushing’s disease (CD) have been recognized as an aggressive and invasive subtype of pituitary adenomas. Remission of CD without surgical or medical treatment is an extremely rare occurrence. Moreover, a clinically relevant peculiarity of these tumors, though rarely observed, is their ability to modify their clinical expression from a silent form to CD or vice versa, the latter even more unexpected. We describe the case ...

Background: Triple A (Allgrove) syndrome is a rare genetic disorder with autosomal recessive inheritance, caused by mutations in the AAAS gene on chromosome 12q13. It is characterized by the following triad: ACTH-resistant adrenal insufficiency, alacrimia, and achalasia.Case presentation: We present the case of a 19-year-old male who was diagnosed with adrenal insufficiency at the age of five following an addisonian crisis with hypoglycemic coma. At the ...

Background: Metabolomics profiling of bio-fluids suggests altered signatures in patients with the polycystic ovary syndrome (PCOS).Subjects and methods: A high-performance liquid chromatography/time-of-flight mass spectrometry (HPLC/TOF-MS)-based metabolomics approach was developed to characterize the untargeted lipidomics signature associated with PCOS status in a discovery cohort of 30 plasma samples (15 PCOS, 15 controls, age-matched), followed in a s...